منابع مشابه
Mitochondrial fission and fusion.
Mitochondria are highly dynamic cellular organelles, with the ability to change size, shape and position over the course of a few seconds. Many of these changes are related to the ability of mitochondria to undergo the highly co-ordinated processes of fission (division of a single organelle into two or more independent structures) or fusion (the opposing reaction). These actions occur simultane...
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Enveloped viruses use specialized protein machinery to attach to host cells and fuse their membrane with the cellular membrane in order to deliver their genetic material for replication. In influenza virus, the trimeric hemagglutinin (HA) glycoprotein spike is responsible for attachment and mediating membrane fusion following endocytosis. While structures of a subset of HA conformations and par...
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Mutations in parkin (PARK2), an ubiquitin ligase, cause early onset Parkinson's disease. Parkin was shown to bind, ubiquitinate, and target depolarized mitochondria for destruction by autophagy. This process, mitophagy, is considered crucial for maintaining mitochondrial integrity and suppressing Parkinsonism. Here, we report that under moderate mitochondrial stress, parkin does not translocate...
متن کاملNeuronal Hypoxia Disrupts Mitochondrial Fusion
Brain ischemia/reperfusion injury results in death of vulnerable neurons and extensive brain damage. It is well known that mitochondrial release of cytochrome c (cyto c) is a hallmark of neuronal death, however the molecular events underlying this release are largely unknown. We tested the hypothesis that cyto c release is regulated by breakdown of the cristae architecture maintenance protein, ...
متن کاملDissecting Membrane Insertion of Mitochondrial β-Barrel Proteins
Communication of mitochondria with the rest of the cell requires beta-barrel proteins of the outer membrane. All beta-barrel proteins are synthesized as precursors in the cytosol and imported into mitochondria by the general translocase TOM and the sorting machinery SAM. The SAM complex contains two proteins essential for cell viability, the channel-forming Sam50 and Sam35. We have identified t...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2006
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2006.10.009